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. 2021 Mar 7;48(12):3990–4001. doi: 10.1007/s00259-021-05265-8

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© The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Dynamic FLT-PET simulation images used for method development and validation. a Input data used to generate dynamic simulations. b Labels for all regions in simulated image. c Center slice images from representative simulation frames. d Average TACs for simulation sphere and blood curve regions