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. 2021 Sep 6;11:17691. doi: 10.1038/s41598-021-96460-y

Figure 3.

Figure 3

Effects of oral BD administration (A–F) and co-administration of oral BD and intraperitoneal leptin (G–J) in ob/ob mice. (A) Body weight change, (B) epididymal WAT weight, (C) liver weight, (D) food intake, (E) plasma β-hydroxybutyrate and (F) hypothalamic ATP concentrations in BD single administration experiment. (G) Body weight change, (H) epididymal WAT weight, (I) cumulative food intake, (J) plasma β-hydroxybutyrate and (K) hypothalamic ATP concentrations in leptin and BD co-administration experiment. Values are means ± SEM (A–F, n = 8 for Water, 7 for BD; G–K, n = 6 for Saline + Water, 6 for Leptin + Water, 6 for Leptin + BD). NS, not significant, *P < 0.05 (Bonferroni's test) (A,G,I). NS, not significant, *P < 0.05, **P < 0.01 (Student’s t-test) (B–F, H,J,K).