Figure 1.

HS and DFU share an increased innate immune response enriched in macrophage function. (A) Notable upregulated DEGs shared between HS, HW, and DFU organized by biological function. Numbers in overlapping circles indicate the amount of shared upregulated genes for that respective comparison. Comparisons involving the HW dataset included “day 3 vs. day 1”, “day 6 vs. day 1”, or “day 3 and 6 vs. day 1”. (B) Notable downregulated DEGs shared between HS, HW, and DFU organized by biological function. (C) Enriched biological processes in the analysis of HS, HW, and DFU. DEGs in the HS dataset were used as the background dataset. (D) Enriched biological processes in the analysis of HS and DFU only. DEGs in the HS dataset were used as the background dataset. DEG, differentially expressed gene; HW (3, 6), healing wound, post-wound days 3 and/or 6 vs. day 1; DFU, diabetic foot ulcer.