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. 2021 Aug 24;8:665873. doi: 10.3389/fmed.2021.665873

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Copyright © 2021 Mariottoni, Jiang, Prestwood, Jain, Suwanpradid, Whitley, Coates, Brown, Erdmann, Corcoran, Gregory, Jaleel, Zhang, Harris-Tryon and MacLeod.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophages in HS lesions show upregulation of markers associated with Fc signaling and metabolic activity. (A) Dot plot showing the percent expressed and average expression of genes related to phagocytosis and metabolic activity between key cellular populations in HS skin. (B) Violin plots for the monocyte/macrophage cluster of genes related to Fc signaling. (C) Violin plots for the monocyte/macrophage cluster of genes related to respiratory burst. cDC, conventional dendritic cell; HC, healthy control; pDC, plasmacytoid dendritic cell.