Table 1.
Genes related to Fcγ signaling are upregulated in monocytes/macrophages of HS lesions compared to healthy control skin.
| Gene | Protein | log2FC | p-value | Function in Fc signaling | Downstream effects | Ref. |
|---|---|---|---|---|---|---|
| FCGR1A | FcγRIa (CD64a) | 1.28 | 5.09E-24 | Activating receptor | ADCC; phagocytosis; cytokine secretion | (54–56) |
| FCGR1B | FcγRIb (CD64b) | 0.732 | 1.97E-9 | Activating receptor | ADCC; phagocytosis; cytokine secretion | (54–56) |
| FCGR2A | FcγRIIa (CD32a) | 0.548 | 4.00E-4 | Activating/inhibitory receptor | Phagocytosis; cytokine secretion | (56, 57) |
| FCGR3A | FcγRIIIa (CD16a) | 0.704 | 1.11E-11 | Activating/inhibitory receptor | ADCC; phagocytosis; cytokine secretion; respiratory burst | (58–60) |
| FCGR3B | FcγRIIIb (CD16b) | 1.23 | 3.26E-12 | Activating/inhibitory receptor | Phagocytosis; neutrophil degranulation; respiratory burst | (59, 60) |
| LYN | Lyn | 1.24 | 2.33E-32 | Tyrosine kinase | Proliferation; migration; cytokine secretion (activation/inhibition) | (61) |
| PTPN6 | SHP-1 | 0.708 | 1.62E-10 | Tyrosine phosphatase | Phagocytosis (inhibition) | (62) |
| SYK | SYK | 0.266 | 2.79E-3 | Tyrosine kinase | Cytokine secretion; respiratory burst (activation) | (63) |
For genes encoding Fcγ receptors, activation/inhibition function is represented in “Function in Fc signaling” column. For genes encoding tyrosine kinase/phosphatase, activation/inhibition function is represented in “Downstream effects” column. log2FC of gene expression was calculated by comparing HS samples to healthy control skin within the monocyte/macrophage clusters. ADCC, antibody-dependent cellular cytotoxicity; FC, fold change; SHP-1, Src homology region 2 domain-containing phosphatase-1.