Table 2.
Interferon-γ stimulated genes are upregulated in monocytes/macrophages from HS lesions compared to healthy skin.
| Gene | log2FC | p-value |
|---|---|---|
| GBP1 | 2.06 | 1.43E-33 |
| GBP2* | 1.03 | 7.88E-15 |
| GBP3 | 0.466 | 2.40E-6 |
| GBP4 | 1.47 | 1.23E-25 |
| GBP5 | 2.47 | 1.99E-39 |
| B2M | 0.888 | 2.66E-74 |
| HLA-A* | 0.914 | 1.75E-51 |
| HLA-B* | 0.985 | 2.07E-70 |
| HLA-C* | 1.60 | 1.95E-83 |
| HLA-E* | 0.440 | 1.73E-9 |
| HLA-F* | 0.905 | 1.69E-20 |
| HLA-DRB5 | 1.24 | 1.43E-15 |
| IFI30 | 0.288 | 2.72E-5 |
| IRF1* | 1.55 | 1.24E-34 |
| IRF2* | 0.475 | 2.31E-5 |
| IRF7* | 0.518 | 2.70E-8 |
| IRF9* | 0.543 | 1.46E-6 |
| FCGR1A | 1.28 | 5.09E-24 |
| FCGR1B | 0.732 | 1.97E-9 |
| OAS1* | 0.304 | 3.47E-7 |
| SP100 | 0.578 | 2.58E-6 |
| ICAM1 | 0.355 | 2.49E-3 |
| CD44 | 0.722 | 2.09E-13 |
| PTAFR | 0.676 | 2.71E-10 |
| PML | 0.381 | 1.92E-4 |
| TRIM21 | 0.305 | 2.47E-5 |
| TRIM22 | 0.459 | 1.17E-2 |
| TRIM25 | 0.312 | 1.46E-2 |
| TRIM38 | 0.599 | 3.20E-9 |
Upregulated genes have γ interferon-activated sequence (GAS) elements in the promoter regions of IFN-stimulated genes (ISGs). log2FC of gene expression was calculated by comparing HS samples to healthy control skin within the monocyte/macrophage clusters.
*
These genes have both interferon-sensitive response elements (ISREs) and GAS in their promoters.