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. 2021 Aug 24;13:717263. doi: 10.3389/fnagi.2021.717263

FIGURE 6.

FIGURE 6

Comparative assessment of Shank3 IR relative to that of general synaptic markers and specific neuronal markers in the striatum. Low power views on the putamen (Pu) and globulus pallidum (GP) and enlarged areas are as indicated. The overall intensity of Shank3 (A,D), postsynaptic density protein 95 (PSD95, B,E), synaptophysin (C,F), vesicular glutamate transport 2 (VGLUT2, G,J), and choline acetyltransferase (ChAT, I,L) IR are heavier in the Pu than the GP. In contrast, the intensity of the glutamate decarboxylase 67 (GAD67) IR is greater in the GP than the Pu (H,K). Besides neuropil reactivity, Shank3, VGLUT2, and ChAT IR occur in a population of large-sized multipolar neurons (D,J,L), whereas GAD67 IR marks relatively small-sized neurons in round, oval or bipolar shape (H). Punctate profiles of VGLUT2 IR are seen around the small-sized neurons in the Pu (J). Abbreviations are as defined in Figure 5. Scale bars are as indicated in each panel.