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CTX-M-15 architecture. (A) The structure of CTX-M-15 (white surface) features two subdomains, an α + β sandwich domain (orange) and an α-helical domain (blue). (B) Similar to other Class A β-lactamases, CTX-M-15 features the conserved Ω-loop, the 240-loop, the 270-loop, and the SDN-loop. (C) The CTX-M-15 is lined with a set of canonical residues, include the active site serine S70.
