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Structural alignment of CTX-M-1-sub family apo structures. (A) Alignment of CTX-M-15 (green, 4HBT) CTX-M-64 (blue, 5ZB7), and CTX-M-96 (pink, 3ZNY). Global β-lactamase fold architecture is conserved. (B) Comparison of CTX-M-15 and CTX-M-64 A67P and V133T mutations. These two mutations are the closest to the active site. Other mutations are mainly located in the α-helical bundle.
