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. 2021 Aug 24;12:688509. doi: 10.3389/fmicb.2021.688509

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Copyright © 2021 Shurina and Page.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CTX-M-15 structures in complex with DABCOs. (A) Structure of CTX-M-15 with bound Avibactam (4HBU). (B) Alternate structure of CTX-M-15 bound to Avibactam (4S2I). (C) Structure of CTX-M-15 and FPI-1523 (5FA7). (D) Structure of CTX-M-15 in complex with FPI-1465 (5FAO). (E) Structure of CTX-M-15 and FPI-1602 (5FAP). (F) Structure of CTX-M-15 in complex with Relebactam. (G) Overlay of active site residues of CTX-M-15 and all DABCO structures.