TABLE 1.

Summary of CTX-M subfamily 1 structures.

Enzyme	PDB ID	Year released	Resolution	Structure type	Active site ligand	Potency or binding data
CTX-M-15	4HBT	2013	1.1	apo	None	NA
CTX-M-15	4HBU	2013	1.1	Diazabicyclooctane	Avibactam	Kd 0.002 uM (Ehmann et al., 2013)
CTX-M-15	4S2I	2015	1.6	Diazabicyclooctane	Avibactam	Kd 0.002 uM (Ehmann et al., 2013)
CTX-M-15	4XUZ	2015	1.5	Boronic acid transition-state analog	RPX-7009 (vaborbactam)	Ki 0.044 uM (Hecker et al., 2015)
CTX-M-15	5FA7	2016	1.67	Diazabicyclooctane	FPI-1523	Kd 0.004 uM (King et al., 2016)
CTX-M-15	5FAO	2016	3.01	Diazabicyclooctane	FPI-1465	Kd 0.011 uM (King et al., 2016)
CTX-M-15	5FAP	2016	2.7	Diazabicyclooctane	FPI-1602	Kd 0.010 uM (King et al., 2016)
CTX-M-15	5T66	2017	1.95	Boronic acid transition-state analog	1C	IC50 1.7 ± 0.1 (nM) (Cahill et al., 2017)
CTX-M-15	6QW8	2019	1.1	Diazabicyclooctane	Relebactam	IC50 400 (nM) (Tooke et al., 2019b)
CTX-M-15	6SP6	2020	1.1	Boronic acid transition-state analog	Taniborbactam (VNRX-5133)	IC50 0.01 uM (Liu et al., 2020)
CTX-M-64	5ZB7	2019	1.63	apo	None	N.A.
CTX-M-64	6ITY	2019	2.14	β-lactam containing	Sulbactam	IC50 0.365 nM (Cheng Q. et al., 2019)
CTX-M-64 (TDN)	6J25	2019	1.2	apo-Mutant	None	NA
CTX-M-64 (TDN)	6J2B	2019	1.44	β-lactam containing-mutant	Sulbactam	IC50 2.21 × 106 nM (Cheng Q. et al., 2019)
CTX-M-64 (TDN)	6J2K	2019	1.44	β-lactam containing-mutant	Clavulanic acid	IC50 4.29 × 101 nM (Cheng Q. et al., 2019)
CTX-M-64	6J2O	2019	1.9	β-lactam containing	Clavulanic acid	IC50 2.28 nM (Cheng Q. et al., 2019)
CTX-M-96	3ZNY	2014	1.2	apo	None	NA