Table 2. Subgroup analyses of OS and CSS.
| Variables | No. of included studies | HR [95% CI], type 2 vs. type 1 | P-value | Heterogeneity | |
|---|---|---|---|---|---|
| I2 (%) | P-value | ||||
| OS | |||||
| Analysis method | |||||
| Multivariate | 10 | 1.22 [0.97, 1.53] | 0.27 | 64 | 0.003 |
| Univariate | 4 | 2.73 [1.78, 4.19] | <0.01 | 15 | 0.32 |
| Sample size | |||||
| <200 cases | 10 | 1.68 [1.02, 2.76] | 0.04 | 70 | 0.0004 |
| ≥200 cases | 4 | 1.45 [0.73, 2.88] | 0.29 | 62 | 0.05 |
| Follow-up | |||||
| <60 months | 8 | 1.77 [0.93, 3.37] | 0.08 | 75 | 0.0002 |
| ≥60 months | 6 | 1.47 [0.92, 2.35] | 0.11 | 55 | 0.05 |
| CSS | |||||
| Analysis method | |||||
| Multivariate | 6 | 1.16 [0.67, 2.00] | 0.60 | 39 | 0.14 |
| Univariate | 6 | 2.17 [1.09, 4.34] | 0.03 | 46 | 0.10 |
| Sample size | |||||
| <200 cases | 8 | 2.36 [1.18, 4.71] | 0.01 | 49 | 0.06 |
| ≥200 cases | 4 | 1.06 [0.76, 1.49] | 0.73 | 0 | 0.70 |
| Follow-up | |||||
| <60 months | 8 | 1.27 [0.81, 2.00] | 0.21 | 24 | 0.24 |
| ≥60 months | 4 | 1.50 [0.91, 2.47] | 0.12 | 49 | 0.12 |
CSS, cancer-specific survival; OS, overall survival; HR, hazard ratio.