Figure 3.

Network analysis identifying YWHAG, YWHAZ, LMNA, and HNRNPA2B1 as important proteins involved in organismal abnormalities and the process of cancer cell proliferation and regulation. In this protein interaction network, it can be observed that YWHAG, YWHAZ, LMNA, and HNRNPA2B1 could directly interact with histones, and may participate in MAPK/ERK-mediated molecular regulatory networks, which shows the credibility of our mass spectrometry data. Green indicates proteins that were significantly downregulated, whereas red indicates proteins that were significantly upregulated. Shapes indicate different functional categories of proteins (as defined in the inset). Lines indicate interactions among proteins within the network (as defined in the inset). Arrowheads indicate stimulatory interactions, whereas endcaps indicate inhibitory interactions. Solid lines indicate direct interactions, whereas dashed lines indicate indirect interactions. Red star-labeled proteins are the differential proteins identified in this experiment. Blue-star-labeled proteins are proteins mentioned in the literature, and purple-star-labeled proteins are closely related proteins.