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. 2021 Aug 24;12:723566. doi: 10.3389/fimmu.2021.723566

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Copyright © 2021 Penny, Abelin, Malaker, Myers, Saeed, Steadman, Bai, Ward, Shabanowitz, Hunt and Cobbold

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TILs target phosphopeptides found on CRC tumors. (A) Immunohistochemistry (IHC) of the tumors that TILs were taken from, stained for CD3, CD8, CD45RO and Granzyme B (DAB staining in brown). Some slide images unavailable due to loss of section. (B) ICS gating strategy utilized in assessment of TIL phosphopeptide responses. (C) CRCLM1 TIL cytokine responses to phosphopeptides identified on CRCLM1 (results represent the assay repeated on 2 separate occasions, with differentially expanded TILs), pie charts show the proportion of T cells producing 1 (blue), 2 (pink) and 3 (purple) cytokines. Consistently strong responses are highlighted in purple. (D) CRCLM2 TIL cytokine responses to phosphopeptides identified on CRCLM2. (E) CRC3 TIL cytokine responses to phosphopeptides identified on CRC3, pie chart shows the proportion of T cells producing 1 (blue), 2 (pink) and 3 (purple) cytokines.