Table 2. Univariate and multivariate Cox regression analyses of the prognostic factors for disease-free survival.
| Characteristics | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Age | 0.762 | 0.524–1.108 | 0.155 | – | |||
| Gender | 0.828 | 0.533–1.286 | 0.401 | – | |||
| T | 1.421 | 1.159–1.742 | 0.001 | 0.815 | 0.569–1.168 | 0.265 | |
| N | 1.468 | 1.273–1.693 | 0.000 | 1.066 | 0.815–1.393 | 0.642 | |
| Stage | 2.690 | 1.962–3.688 | 0.000 | 2.586 | 1.223–5.468 | 0.013 | |
| Lauren’s classification | 1.107 | 0.833–1.472 | 0.483 | – | |||
| Vascular invasion | 1.464 | 1.003–2.137 | 0.048 | 1.160 | 0.790–1.703 | 0.449 | |
| Nerve invasion | 1.240 | 0.852–1.805 | 0.262 | – | |||
| Anemia | 1.310 | 0.886–1.937 | 0.175 | – | |||
| HER2 | 1.160 | 0.742–1.813 | 0.514 | – | |||
| Site | 0.927 | 0.786–1.094 | 0.369 | – | |||
| Smoking | 1.415 | 0.960–2.087 | 0.080 | – | |||
| Drinking | 1.178 | 0.767–1.809 | 0.455 | – | |||
| Diabetes | 1.673 | 0.937–2.985 | 0.082 | – | |||
| Hepatitis B | 1.523 | 0.955–2.431 | 0.078 | – | |||
| Helicobacter pylori | 1.385 | 0.932–2.058 | 0.107 | – | |||
| Treatment | 1.684 | 1.281–2.213 | 0.000 | 1.181 | 0.852–1.639 | 0.318 | |
| AAPR | 4.407 | 2.623–7.405 | 0.000 | 4.068 | 2.403–6.886 | 0.000 | |
HR, hazard ratio; CI, confidence interval; AAPR, albumin-to-alkaline phosphatase ratio.