Table 3. Univariate and multivariate Cox regression analyses of the prognostic factors for overall survival.
| Characteristics | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Age | 0.658 | 0.437–0.989 | 0.044 | 0.797 | 0.527–1.207 | 0.285 | |
| Gender | 0.810 | 0.498–1.317 | 0.395 | – | |||
| T | 1.493 | 1.202–1.855 | 0.000 | 0.833 | 0.569–1.219 | 0.347 | |
| N | 1.457 | 1.249–1.701 | 0.000 | 1.017 | 0.762–1.358 | 0.907 | |
| Stage | 2.964 | 2.089–4.206 | 0.000 | 2.777 | 1.224–6.305 | 0.015 | |
| Lauren’s classification | 0.986 | 0.715–1.361 | 0.934 | – | |||
| Vascular invasion | 1.539 | 1.021–2.320 | 0.040 | 1.181 | 0.778–1.792 | 0.434 | |
| Nerve invasion | 1.293 | 0.860–1.942 | 0.217 | – | |||
| Anemia | 1.387 | 0.909–2.117 | 0.130 | – | |||
| HER2 | 0.942 | 0.563–1.576 | 0.820 | – | |||
| Site | 0.983 | 0.820–1.179 | 0.854 | – | |||
| Smoking | 1.304 | 0.852–1.994 | 0.221 | – | |||
| Drinking | 1.123 | 0.701–1.799 | 0.629 | – | |||
| Diabetes | 1.258 | 0.632–2.503 | 0.513 | – | |||
| Hepatitis B | 1.298 | 0.767–2.196 | 0.332 | – | |||
| Helicobacter pylori | 1.173 | 0.756–1.819 | 0.477 | – | |||
| Treatment | 1.892 | 1.393–2.570 | 0.000 | 1.335 | 0.929–1.917 | 0.118 | |
| AAPR | 4.966 | 2.706–9.112 | 0.000 | 4.114 | 2.222–7.616 | 0.000 | |
HR, hazard ratio; CI, confidence interval; AAPR, albumin-to-alkaline phosphatase ratio.