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. 2021 Aug;12(4):1625–1642. doi: 10.21037/jgo-21-467

Figure 2.

Figure 2

Combined application of CTX and PP242 inhibits the growth of xenograft tumors in mice without significant toxicity. Six-week-old male BALB/c nude mice bearing HT-29 cell xenograft tumors were untreated or treated with 20 mg/kg CTX and 30 mg/kg PP242 alone or in combination twice a week. (A) Mouse xenograft tumor volumes during 2 weeks of treatment. (B) Mouse body weights during 2 weeks of treatment. (C) Mouse xenograft tumors from all groups. (D) Microscopic view of HE staining of mouse heart, liver, spleen, lung, and kidney sections. Data are shown as the mean ± SEM. Scale bar: 50 µm. *, P<0.05 and **, P<0.01 when compared with the control group; #, P<0.05 when compared with the CTX group. CTX, cetuximab; HE, hematoxylin-eosin; SEM, standard error of mean.