Table 1. Association of uPA expression with clinicopathological features in HCC.
| Clinicopathological features | Number of cases (n) | uPA expression, n (%) | P value | |
|---|---|---|---|---|
| Low | High | |||
| Age | 0.287 | |||
| ≤60 | 103 | 66 (64.1) | 37 (35.9) | |
| >60 | 30 | 16 (53.3) | 14 (46.7) | |
| Sex | 0.323 | |||
| Male | 118 | 71 (60.2) | 47 (39.8) | |
| Female | 15 | 11 (73.3) | 4 (26.7) | |
| Cirrhosis | 0.708 | |||
| Positive | 102 | 62 (60.8) | 40 (39.2) | |
| Negative | 31 | 20 (64.5) | 11 (35.5) | |
| Tumor size | 0.015 | |||
| ≤5 cm | 70 | 50 (71.4) | 20 (28.6) | |
| >5 cm | 63 | 32 (50.8) | 31 (49.2) | |
| Microsatellite formation | 0.747 | |||
| Absent | 96 | 60 (62.5) | 36 (37.5) | |
| Present | 37 | 22 (59.5) | 15 (40.5) | |
| Tumor encapsulation | 0.010 | |||
| Absent | 52 | 25 (48.4) | 27 (51.9) | |
| Present | 81 | 57 (70.4) | 24 (29.6) | |
| Vascular invasion | 0.908 | |||
| Absent | 105 | 65 (61.9) | 40 (38.1) | |
| Present | 28 | 17 (60.7) | 11 (39.3) | |
| Differentiation grade | 0.028 | |||
| Grade 1–2 | 83 | 57 (68.7) | 26 (31.3) | |
| Grade 3–4 | 45 | 22 (48.9) | 23 (51.1) | |
| AFP | 0.959 | |||
| ≤400 | 76 | 47 (61.8) | 29 (38.2) | |
| >400 | 57 | 35 (61.4) | 22 (38.6) | |
| HBsAg | 0.638 | |||
| Negative | 18 | 12 (66.7) | 6 (33.3) | |
| Positive | 115 | 70 (60.9) | 45 (39.1) | |
uPA, urokinase plasminogen activator; HCC, hepatocellular carcinoma; AFP, alpha-fetoprotein; HBsAg, hepatitis B virus surface antigen.