Table 3. Demographic characteristics of GBC patients with and without hyperfibrinogenemia.
| Variable | Preoperative plasma fibrinogen | P value* | |
|---|---|---|---|
| ≤4.43 g/L (N=120) | >4.43 g/L (N=54) | ||
| Female sex | 88 (73.3%) | 31 (57.4%) | 0.06 |
| Age | 65.4±11.5 | 70.5±12.2 | 0.01 |
| Moderate/poor differentiation | 105 (87.5%) | 50 (92.6%) | 0.46 |
| T2–T4, AJCC 7th ed | 100 (83.3%) | 50 (92.6%) | 0.16 |
| Positive lymph node | 37 (30.8%) | 26 (48.1%) | 0.04 |
| Concomitant cholelithiasis | 72 (60.0%) | 37 (68.5%) | 0.37 |
| TBIL, μmol/L (median, range) | 14.8 (2–373) | 13.6 (4.7–273) | 0.92 |
| CA199, U/mL (median, range) | 33.7 (0.6–6,375) | 40.6 (0.6–5,722) | 0.62 |
| CA125, U/mL (median, range) | 20.2 (1.6–349) | 55.3 (1.6–742) | <0.001 |
| CEA, ng/mL (median, range) | 3.0 (0.3–152) | 3.7 (0.27–285) | 0.007 |
| INR | 1.01±0.12 | 1.04±0.13 | 0.21 |
*, χ2 test for discrete variables. T-test or Mann-Whitney U test for continuous variables. Italic P values indicate P<0.05. GBC, gallbladder cancer.