Table 3. Temporal trends of attainment of guideline LDL-C targets among different risk groups.
| Variables | Total (N=858,509) | 2015 (N=21,504, 2.5%) | 2016 (N=183,177, 21.3%) | 2017 (N=214,133, 24.9%) | 2018 (N=275,810, 32.1%) | 2019 (N=163,885, 19.1%) | Relative increase rate (%) | P for trend |
|---|---|---|---|---|---|---|---|---|
| Preexisting CeVD | ||||||||
| LDL-C <2.6 mmol/L | 124,927 (49.7) | 3,245 (49.3) | 24,962 (48.5) | 28,909 (48.6) | 40,142 (50.1) | 27,669 (51.8) | 5.1 | <0.0001 |
| LDL-C <1.8 mmol/L | 45,008 (17.9) | 1,142 (17.4) | 8,673 (16.8) | 10,086 (16.9) | 14,748 (18.4) | 10,359 (19.4) | 11.5 | <0.0001 |
| LDL-C <1.4 mmol/L | 19,932 (7.9) | 511 (7.8) | 3,677 (7.1) | 4,464 (7.5) | 6,601 (8.2) | 4,679 (8.8) | 12.8 | <0.0001 |
| Discharged on statins | 222,328 (88.5) | 5,822 (88.5) | 45,908 (89.2) | 52,703 (88.5) | 70,338 (87.8) | 47,557 (89.0) | 0.6 | 0.0207 |
| Preexisting CVD | ||||||||
| LDL-C <2.6 mmol/L | 22,193 (50.3) | 707 (50.6) | 6,181 (49.4) | 6,859 (49.6) | 7,693 (51.2) | 753 (54.6) | 8.0 | 0.0002 |
| LDL-C <1.8 mmol/L | 7,676 (17.4) | 241 (17.3) | 2,053 (16.4) | 2,336 (16.9) | 2,741 (18.2) | 305 (22.1) | 27.7 | <0.0001 |
| LDL-C <1.4 mmol/L | 3,349 (7.6) | 110 (7.9) | 908 (7.3) | 1,021 (7.4) | 1,177 (7.8) | 133 (9.6) | 21.5 | 0.0138 |
| Discharged on statins | 39,440 (89.3) | 1,227 (87.9) | 11,169 (89.2) | 12,477 (90.2) | 13,309 (88.6) | 1,258 (91.2) | 3.8 | 0.9931 |
| Preexisting concomitant CeVD and CVD | ||||||||
| LDL-C <2.6 mmol/L | 17,375 (52.5) | 658 (51.2) | 4,679 (51.5) | 5,120 (51.7) | 6,279 (54.1) | 639 (53.6) | 4.7 | 0.0001 |
| LDL-C <1.8 mmol/L | 6,856 (20.7) | 282 (21.9) | 1,829 (20.1) | 2,003 (20.2) | 2,449 (21.1) | 293 (24.6) | 12.3 | 0.0265 |
| LDL-C <1.4 mmol/L | 3,030 (9.2) | 136 (10.6) | 770 (8.5) | 909 (9.2) | 1,073 (9.2) | 142 (11.9) | 12.3 | 0.0456 |
| Discharged on statins | 29,414 (88.9) | 1,135 (88.3) | 8,013 (88.2) | 8,806 (88.9) | 10,392 (89.5) | 1,068 (89.6) | 1.5 | 0.0028 |
| No history of CeVD/CVD | ||||||||
| LDL-C <2.6 mmol/L | 233,101 (44.0) | 5,491 (44.9) | 47,708 (43.3) | 56,636 (43.3) | 74,490 (44.1) | 48,776 (45.2) | 0.7 | <0.0001 |
| LDL-C <1.8 mmol/L | 68,637 (12.9) | 1,717 (14.0) | 13,979 (12.7) | 16,196 (12.4) | 21,877 (12.9) | 14,868 (13.8) | −1.4 | <0.0001 |
| LDL-C <1.4 mmol/L | 28,964 (5.5) | 737 (6.0) | 5,860 (5.3) | 6,836 (5.2) | 9,206 (5.4) | 6,325 (5.9) | −1.7 | <0.0001 |
| Discharged on statins | 475,499 (89.7) | 10,871 (88.8) | 99,408 (90.3) | 117,228 (89.6) | 150,886 (89.3) | 97,106 (90.0) | 1.4 | 0.0402 |
CeVD, cerebrovascular disease; CVD, cardiovascular disease; LDL-C, low-density lipoprotein cholesterol.