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. 2021 Aug;9(15):1264. doi: 10.21037/atm-21-525

Figure 2.

Figure 2

Variant allele frequency dynamics over time in cell-free DNA and white blood cells with corresponding PET-CT images. Images from left to right: baseline PET-CT image showing FDG-avid esophageal tumor; CRE-II (t=3) PET-CT image showing radiologically complete response to nCRT; PET-CT image at 21 months after baseline (t=5) showing FDG-avid lesion suspect for metastasis within the semimembranosus muscle; PET-CT image 26 months after baseline (t=7) of semimembranosus lesion showing decreased intensity after induction chemotherapy; PET-CT image 30 months after baseline (t=9) showing FDG-avid lesions suspect for metastasis within the adductor muscles of the right lower extremity, bilaterally in the pelvic acetabulum and in the transverse process of a thoracic vertebra. VAF, variant allele frequency; cfDNA, cell-free deoxyribonucleic acid; WBCs, white blood cells; PET-CT, positron emission tomography-computed tomography; nCRT, neoadjuvant chemoradiotherapy; FDG, 18-fluoride-fluorodeoxyglucose; CRE-II clinical response evaluation-II.