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. 2021 Aug;9(16):1341. doi: 10.21037/atm-21-3930

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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CircMMP1 is upregulated in colorectal cancer with circular features. (A) High-throughput microarray sequencing from 5 pairs of CRC samples screened the significantly differentially expressed circRNAs. (B) Top 5 upregulated circRNA between CRC tissues and adjacent normal colorectal tissues was detected by qPCR analysis. (C) The relative expression level of circMMP1 in NCM460 and CRC cells. (D) The circular feature of circMMP1 was examined by RNase R assay in SW620. (E) Determined by actinomycin D treated assay, circular transcripts of circMMP1 were more stable than its linear MMP1 mRNA transcripts in SW620 CRC cell line. **P<0.01. CRC, colorectal cancer; qPCR, quantitative polymerase chain reaction.