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. 2021 Aug;9(16):1341. doi: 10.21037/atm-21-3930

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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CircMMP1 silencing suppressed the proliferation and invasion of CRC cells in vitro. (A) The efficacy of knockdown was verified in SW480 and SW620 CRC cell lines, assessing by qRT-PCR analysis. (B) The proliferation of cells in SW480 and SW620 was evaluated by CCK-8 assay. (C) Colony-formation assay was conducted with 3 different cell concentrations (0.5% crystal violet staining). (D) Statistical chart of Colony-formation assay. (E) The invasion ability of colorectal cancer cell SW620 was investigated by transwell assay (0.5% crystal violet staining). **P<0.01. CRC, colorectal cancer.