Table 2. Estimated cumulative effects (lag_0-21) on YLL under different patterns of temperature relative to the YLL at the reference temperature.

Variables	Overall YLL	OT (°C)	Extreme cold * (years, 95% CI)	Mild cold * (years, 95% CI)	Mild heat * (years, 95% CI)	Extreme heat * (years, 95% CI)
Abbreviations: YLL=years of life lost; OT=optimum temperature. The reference temperature was set at the temperature with lowest YLL. * Extreme cold, mild cold, extreme hot, and mild hot temperature were defined as 2.5th, 25th, 97.5th and 75th percentile of temperature distribution, respectively, compared with the reference temperature (minimum YLL temperature).
Overall region	16,793,014.0	25.6	19.77 (11.16, 28.40)	15.34 (7.77, 22.91)	2.99 (0.49, 5.49)	5.47 (2.57, 8.37)
Northeast	3,562,080.8	23.2	53.73 (8.91, 98.55)	30.15 (−5.48, 65.77)	23.96 (4.88, 43.04)	21.16 (0.45, 41.88)
Northwest	979,861.7	17.0	12.51 (−22.04, 47.05)	14.57 (−18.83, 47.97)	1.13 (−17.55, 19.80)	10.53 (−5.84, 26.90)
North	1,573,462.6	24.9	41.67 (3.70, 79.64)	46.61 (7.83, 85.39)	11.95 (−4.68, 28.)	11.39 (−0.07, 22.85)
Central	2,380,406.4	16.7	22.28 (−16.52, 61.07)	15.58 (−17.04, 48.20)	0.01 (−0.56, 0.59)	17.09 (−2.79, 36.97)
East	5,413,438.8	25.2	21.80 (8.38, 35.23)	7.38 (−5.65, 20.41)	1.69 (−3.35, 6.72)	18.90 (9.89, 27.90)
Southwest	1,786,702.7	27.7	54.18 (9.90, 29.19)	16.54 (7.86, 25.21)	3.34 (0.01, 6.68)	4.41 (2.31, 6.51)
South	1,097,060.8	28.7	84.98 (22.29, 147.68)	32.24 (−1.88, 66.37)	3.99 (−11.59, 19.57)	2.24 (−8.18, 12.66)
Subtype
Hemorrhagic stroke	9,852,444.0	28.2	11.62 (4.51, 18.73)	10.53 (4.08, 16.97)	3.13 (0.13, 6.12)	0.36 (−0.60, 1.32)
Ischemic stroke	6,028,666.0	22.4	7.55 (3.50, 11.60)	4.63 (1.18, 8.08)	0.03 (−0.20, 0.25)	6.33 (3.64, 9.01)
Sex
Male	10,033,788.0	26.0	13.05 (6.87, 19.24)	10.57 (5.32, 15.81)	2.09 (−0.02, 4.21)	2.43 (0.71, 4.17)
Female	6,759,226.0	25.1	5.53 (0.92, 10.15)	4.19 (0.04, 8.34)	0.84 (−0.53, 2.21)	2.45 (0.76, 4.13)