Table 7.
Studies on vaccination response under prednisone and DMARDs (no COVID-19 vaccinations)
| Compound | Data on vaccination response |
|---|---|
| Prednisone [79–81] | > 10 mg Prednisone (dose-dependent) limited humoral response |
| csDMARDs | |
| Methotrexate [82–85] | Decreased humoral response (influenza, pneumococcus) |
| Mycophenolate [75] | Decreased humoral response |
| Other csDMARDs [86–89] | Limited, but acceptable humoral response |
| bDMARDs | |
| TNF inhibitors [81, 86, 90–92] | Limited, but acceptable humoral response (influenza) |
| IL-6‑R inhibitors [93–95] | Unimpaired humoral response |
| Abatacept [95–97] | Inconsistent data |
| Rituximab [82, 98–100] | Significantly impaired humoral response (pneumococcus, influenza) |
|
tsDMARDs |
Uninpaired humoral/cellular response (pneumococcus) Impaired humoral response (tetanus) |