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. 2021 Aug 20;22(5):1197. doi: 10.3892/etm.2021.10631

Figure 1.

Figure 1

Effect of AS-IV on the EDRs of aortas obtained from diabetic mice. (A) Representative recording traces revealed that impaired ACh-induced aortic EDRs from DM mice were restored following treatment with AS-IV (12 mg/kg). ACh (10-9, 10-8.5, 10-8, 10-7.5, 10-7, 10-6.5, 10-6, 10-5.5, 10-5 M) was applied to the organ bath at points indicated by solid black spots. (B) Summative graphs demonstrated that AS-IV (6 and 12 mg/kg) treatment improved aortic EDRs in DM mice. (C) EDRs in response to ACh following 30 min exposure to L-NAME were presented in aortas obtained from the 5 groups of mice. Data are presented as the mean ± SEM (n=6-8). ***P<0.001 vs. control mice. ##P<0.01 and ###P<0.001 vs. mice with DM. AS-IV, Astragaloside IV; EDRs, endothelium-dependent relaxations; DM, diabetes mellitus; ACh, acetylcholine; L-NAME, NG-nitro-L-arginine; Phe, phenylephrine.