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. 2021 Aug 20;22(5):1197. doi: 10.3892/etm.2021.10631

Figure 2.

Figure 2

Effect of AS-IV on ACh-induced vasoconstriction in the aortae of diabetic mice. (A) Representative recording traces demonstrated that augmented ACh-induced EDCs in the aortae of DM mice were prevented following AS-IV (12 mg/kg) treatment. ACh (10-8, 10-7.5, 10-7, 10-6.5, 10-6, 10-5.5, 10-5, 10-4.5, 10-4 M) was applied to the organ bath at points indicated by solid black spots. (B) Summative graphs revealed that AS-IV (6 and 12 mg/kg) treatment reduced EDCs in the aortae of DM mice. Data are presented as the mean ± SEM (n=6-8). ***P<0.001 vs. control mice; #P<0.05 and ###P<0.001 vs. mice with DM. AS-IV, Astragaloside IV; ACh, acetylcholine; DM, diabetes mellitus; EDCs, endothelium-dependent contractions.