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. 2021 Aug 20;22(5):1197. doi: 10.3892/etm.2021.10631

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of AS-IV on ROS generation in the aortae of diabetic mice. (A) Representative photomicrographs of dihydroethidium-stained thoracic aorta sections from the (a) control, (b) DM and at (c) 3, (d) 6 and (e) 12 mg/kg DM+AS-IV groups (magnification, x200). (B) Analysis of ROS fluorescence intensity from (A). ELISA analysis of aortic (C) T-SOD (U/ml) and (D) malondialdehyde (mmol/mg). Data are presented as the mean ± SEM (n=6-8). ^*P<0.05 and ^**P<0.01 vs. the control group. ^#P<0.05 vs. the DM group. AS-IV, Astragaloside IV; DM, diabetes mellitus; ROS, reactive oxygen species; T-SOD, superoxide dismutase; T-SOD, Total-superoxide dismutase; MDA, malondialdehyde.