Table I.

Effect of AS-IV on the E_max and pD2 values of ACh-induced relaxation and contraction dose-response curves of the aortas isolated from control, DM and DM+AS-IV (3, 6, 12 mg/kg) mice.

	ACh (relaxation)		ACh (contraction)
Groups	Emax	pD2	Emax	pD2
Control	89.80±1.62	7.41±0.06	11.54±2.93	5.94±0.25
DM	66.74±4.34b	7.01±0.09a	82.24±4.22a	7.30±0.26a
DM+AS-IV 3 mg/kg	71.23±3.39	6.99±0.09	73.37±3.63	6.92±0.15
DM+AS-IV 6 mg/kg	85.00±1.67d	7.02±0.09	62.25±6.35c	6.33±0.27c
DM+AS-IV 12 mg/kg	86.27±1.38e	7.33±0.07c	52.19±4.66e	6.09±0.35c

Data are expressed as the mean ± SEM (n=6-8).

^aP<0.01 and

^bP<0.001 vs. control mice.

^cP<0.05,

^dP<0.01 and

^eP<0.001 vs. mice with DM. AS-IV, Astragaloside; E_max, maximal response; pD2, (-logEC₅₀); ACh, acetylcholine; DM, diabetes mellitus.