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. 2021 Aug 24;22(5):1212. doi: 10.3892/etm.2021.10646

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Heme oxygenase-1 expression partially reverses fibroblast biological behavioral disorders. (A) In the AGEs + NG + Hemin and AGEs + HG + Hemin group, cells apoptosis did not return to the levels of those in NG group. (B) In the AGEs + NG + Hemin group, cell proliferation was higher than that in the NG group. In the AGEs + HG + Hemin group, cell proliferation was lower than that in the NG group. (C) In the AGEs + NG + Hemin and AGEs + HG + Hemin group, cells migration did not return to the levels of those in the NG group. CrMP abolished the effects of hemin. All experiments were performed in triplicate, and the data are presented as the mean ± SD. ^*P<0.05 NG group vs. AGEs + NG + Hemin group; ^#P<0.05 NG group vs. AGEs + HG + Hemin group; ^&P<0.05 AGEs + NG + Hemin group vs. AGEs + NG + Hemin + CrMP group.