. 2021 Aug 24;22(5):1212. doi: 10.3892/etm.2021.10646

Table I.

Oxidative stress and inflammatory injury index of fibroblasts under different conditions.

Group	ROS, fluorescence intensity	MDA, nmol/ml	8-OHdG, ng/ml	TNF-α, pg/ml	IL-6, pg/ml	IL-1β, pg/ml
NG	214.03±24.91	2.42±0.51	2.99±0.62	8.51±1.84	10.56±2.13	15.25±3.48
NG + Hemin	135.73±12.42^a	1.59±0.23^a	1.41±0.20^a	3.48±0.82^a	4.71±0.82^a	6.59±1.97^a
NG + CrMP	238.46±27.31	2.68±0.65	3.55±0.71	10.72±1.98	12.92±2.99	18.65±4.09
NG + Hemin + CrMP	227.52±23.74	2.51±0.42	3.02±0.63	9.13±1.79	11.37±2.11	16.99±4.31
AGEs + NG	892.48±50.27^a	6.27±0.78^a	8.39±0.85^a	30.81±4.63^a	39.88±5.97^a	48.85±6.27^a
AGEs + NG + Hemin	485.32±38.64^b	3.98±0.71^b	3.22±0.72^b	11.56±2.01^b	21.96±3.63^b	23.26±5.24^b
AGEs + NG + CrMP	917.60±62.84	6.94±0.81	9.78±0.96	38.55±5.09	42.42±6.56	55.43±7.38
AGEs + NG + Hemin + CrMP	901.25±60.35	6.68±0.79	8.52±0.84	32.79±5.11	40.71±6.71	52.83±7.50
AGEs + HG	1,183.73+79.37^a,b	8.83±0.86^a,b	10.97±1.23^a,b	39.63±5.94^a,b	48.68±7.02^a,b	60.13±7.62^a,b
AGEs + HG + Hemin	582.16±41.38^c	4.62±0.76^c	5.63±0.88^c	15.38±2.32^c	22.53±4.39^c	32.86±5.89^c
AGEs + HG + CrMP	1,294.31±83.65	9.41±0.92	12.85±1.40	45.83±6.84	52.50±7.58	65.73±7.97
AGEs + HG + Hemin + CrMP	1,206.39±80.15	8.96±0.83	11.09±1.14	42.09±6.58	50.15±6.91	62.92±7.25

Data are presented as the mean ± SD (n=3).

^aP<0.05 vs. NG group;

^bP<0.05 vs. AGEs + NG group;

^cP<0.05 vs. AGEs + HG group. NG, normal glucose; HG, high glucose; AGEs, advanced glycation end products; CrMP, chromium mesoporphyrin; ROS, reactive oxygen species; MDA, malondialdehyde; 8-OHdG, 8-hydroxydeoxyguanosine.