Table 1.

Research objective described using PICO

Participants	Adult patients with rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis or ankylosing spondylitis
Intervention	Targeted therapies (ie, biological disease-modifying antirheumatic drugs and targeted synthetic disease-modifying antirheumatic drugs)
Comparison	Placebo, standard care or waiting list/no intervention, active comparator and unclear (ie, comparison described in insufficient detail to fit within the other categories)
Outcomes	Number of withdrawals, number of withdrawals due to adverse events, number of serious adverse events and number of patients who died

PICO, participants, intervention, comparison and outcomes.