Table 4.
Odds Ratio and 95 % confidence intervals of the association between liver fibrosis score (FIB-4) and low eGFR (eGFR calculated from CKD-EPI cystatin C equation) and increased urine albumin-to-creatinine ratio (UACR)
| Regression models | Weighted % (SD) | Low eGFR | Increased UACR |
|---|---|---|---|
| OR and 95 %CI | OR and 95 %CI | ||
| Unadjusted model | |||
| Low FIB-4 | 86.5 (0.45) | 1.00 | 1.00 |
| Moderate FIB-4 | 12.5 (0.43) | 7.90 (5.73, 10.89) | 1.87 (1.58, 2.23) |
| High FIB-4 | 1.0 (0.13) | 5.38 (1.99, 14.53) | 4.46 (2.82, 7.05) |
| Model 1 | |||
| Low FIB-4 | 86.5 (0.45) | 1.00 | 1.00 |
| Moderate FIB-4 | 12.5 (0.43) | 1.37 (0.98, 1.93) | 1.12 (0.92, 1.36) |
| High FIB-4 | 1.0 (0.13) | 0.67 (0.24, 1.90) | 2.47 (1.54, 3.96) |
| Model 2 | |||
| Low FIB-4 | 86.5 (0.45) | 1.00 | 1.00 |
| Moderate FIB-4 | 12.5 (0.43) | 1.35 (0.96, 1.90) | 1.18 (0.97, 1.43) |
| High FIB-4 | 1.0 (0.13) | 0.65 (0.23, 1.83) | 2.62 (1.63, 4.20) |
| Model 3 | |||
| Low FIB-4 | 86.5 (0.45) | 1.00 | 1.00 |
| Moderate FIB-4 | 12.5 (0.43) | 1.31 (0.93, 1.83) | 1.15 (0.94, 1.41) |
| High FIB-4 | 1.0 (0.13) | 0.60 (0.21, 1.75) | 2.54 (1.56, 4.13) |
Liver fibrosis score (FIB-4): low (FIB-4 < 1.3), moderate (FIB-4: 1.3–2.67), and high (FIB-4 > 2.67)
Low eGFR defined as eGFR < 60 ml/min/1.73 m2
Increased UACR defined as UACR > 17 mg/g in men and > 25 mg/ g in women
Model 1 adjusted for age, sex, Hispanic/Latino background, and study site
Model 2 adjusted for age, sex, Hispanic/Latino background, study site, and metabolic syndrome
Model 3 adjusted for age, sex, Hispanic/Latino background, study site, metabolic syndrome, education attainment, alcohol consumption, cigarette smoking, having health insurance, use of angiotensin converting enzyme inhibitors/angiotensin receptor blockers, and corticosteroids