Table 2.

Unadjusted and adjusted odds ratios of all biomarkers for malignant brain edema

	Unadjusted		Adjusted a
	OR (95 % CI)	P value	OR (95 % CI)	P value
NLRP3	1.72 (1.06, 2.79)	0.03	1.47 (0.88, 2.46)	0.14
HIF 1α	0.72 (0.37, 1.37)	0.31	0.61 (0.31, 1.20)	0.15
CTSB	1.12 (0.26, 4.95)	0.88	0.80 (0.17, 3.79)	0.78
CASP1	1.14 (0.86, 1.51)	0.36	1.15 (0.86, 1.55)	0.34
MMP9	1.00 (0.97, 1.04)	0.95	1.00 (0.96, 1.04)	0.87

CASP-1, Caspase-1; CI: confidence interval; CTSB, cathepsin B; HIF-1α, hypoxia inducible factor-1α; MMP9, Matrix Metalloproteinase-9; NLRP3, nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3; OR, odds ratio. Data of serum level of biomarkers were Ln-transformed for analysis. ^a adjusted variables included age and National Institutes of Health Stroke Scale score