Table 2.
The allele and genotype distribution of the SNPs in control, CIN and cervical cancer groups
| SNPs | Alleles/Genotypes | Control (n = 998) | CIN (n = 435) | CC (n = 743) | CIN vs Control | CC vs Control | CC vs CIN | |||
|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | P value | OR(95%CI) | P value | OR(95%CI) | P value | OR(95%CI) | ||
| rs1292037 | T | 1123 (56.3) | 513 (59.0) | 875 (58.9) | 0.179 | 0.90 [0.76–1.05] | 0.122 | 0.90 [0.78–1.43] | 0.969 | 1.00 [0.85–1.19] |
| C | 873 (43.7) | 357 (41.0) | 611 (41.1) | |||||||
| T/T | 329 (33.0) | 138 (31.7) | 268 (36.1) | 0.004 | 0.320 | 0.010 | ||||
| T/C | 465 (46.6) | 237 (54.5) | 339 (45.6) | |||||||
| C/C | 204 (20.4) | 60 (13.8) | 136 (18.3) | |||||||
| rs13137 | A | 1121 (56.2) | 512 (58.9) | 874 (58.8) | 0.181 | 1.12 [0.95–1.31] | 0.117 | 1.11 [0.97–1.28] | 0.987 | 1.00 [0.84–1.18] |
| T | 875 (43.8) | 358 (41.1) | 612 (41.2) | |||||||
| A/A | 327 (32.8) | 138 (31.7) | 268 (36.1) | 0.006 | 0.303 | 0.011 | ||||
| A/T | 467 (46.8) | 236 (54.3) | 338 (45.5) | |||||||
| T/T | 204 (20.4) | 61 (14.0) | 137 (18.4) | |||||||
| rs2858061 | G | 1578 (79.1) | 691 (79.4) | 1149 (77.3) | 0.824 | 0.98 [0.80–1.19] | 0.219 | 1.11 [0.94–1.30] | 0.233 | 1.13 [0.92–1.39] |
| C | 418 (20.9) | 179 (20.6) | 337 (22.7) | |||||||
| G/G | 628 (62.9) | 271 (62.3) | 450 (60.6) | 0.436 | 0.453 | 0.171 | ||||
| G/C | 322 (32.3) | 149 (34.3) | 249 (33.5) | |||||||
| C/C | 48 (4.8) | 15 (3.4) | 44 (5.9) | |||||||
| rs34678647 | G | 1615 (80.9) | 684 (78.6) | 1207 (81.2) | 0.157 | 0.87 [0.71–1.06] | 0.816 | 1.02 [0.86–1.21] | 0.125 | 1.18 [0.96–1.45] |
| T | 381 (19.1) | 186 (21.4) | 279 (18.8) | |||||||
| G/G | 662 (66.3) | 263 (60.5) | 490 (65.9) | 0.020 | 0.509 | 0.125 | ||||
| G/T | 291 (29.2) | 158 (36.3) | 227 (30.6) | |||||||
| T/T | 45 (4.5) | 14 (3.2) | 26 (3.5) | |||||||
| rs2858060 | C | 1600 (80.2) | 695 (79.9) | 1162 (78.2) | 0.865 | 0.98 [0.81–1.99] | 0.157 | 0.89 [0.75–1.05] | 0.333 | 0.90 [0.73–1.11] |
| G | 396 (19.8) | 175 (20.1) | 324 (21.8) | |||||||
| C/C | 642 (64.3) | 274 (63.0) | 455 (61.2) | 0.603 | 0.369 | 0.397 | ||||
| C/G | 316 (31.7) | 147 (33.8) | 252 (33.9) | |||||||
| G/G | 40 (4.0) | 14 (3.2) | 36 (4.8) | |||||||
| rs2745709 | C | 1229 (61.6) | 507 (58.3) | 878 (59.1) | 0.097 | 0.87 [0.74–1.03] | 0.137 | 0.90 [0.79–1.03] | 0.7 | 1.03 [0.87–1.22] |
| T | 767 (38.4) | 363 (41.7) | 608 (40.9) | |||||||
| C/C | 381 (38.2) | 129 (29.7) | 260 (35.0) | 0.001 | 0.331 | 0.010 | ||||
| C/T | 467 (46.8) | 249 (57.2) | 358 (48.2) | |||||||
| T/T | 150 (15.0) | 57 (13.1) | 125 (16.8) | |||||||
| rs2297537 | C | 1618 (81.1) | 729 (83.8) | 1172 (78.9) | 0.081 | 1.21 [0.98–1.49] | 0.109 | 0.87 [0.74–1.03] | 0.003 | 0.72 [0.58–0.90] |
| G | 378 (18.9) | 141 (16.2) | 314 (21.1) | |||||||
| C/C | 659 (66.0) | 302 (69.4) | 459 (61.8) | 0.098 | 0.174 | 0.010 | ||||
| C/G | 300 (30.1) | 125 (28.7) | 254 (34.2) | |||||||
| G/G | 39 (3.9) | 8 (1.8) | 30 (4.0) | |||||||
| rs2297538 | G | 1705 (85.4) | 723 (83.1) | 1261 (84.9) | 0.113 | 1.19 [0.96–1.48] | 0.644 | 1.05 [0.87–1.26] | 0.259 | 0.88 [0.70–1.10] |
| A | 291 (14.6) | 147 (16.9) | 225 (15.1) | |||||||
| G/G | 737 (73.8) | 315 (72.4) | 535 (72.0) | 0.016 | 0.339 | 0.001 | ||||
| G/A | 231 (23.1) | 93 (21.4) | 191 (25.7) | |||||||
| A/A | 30 (3.0) | 27 (6.2) | 17 (2.3) | |||||||
| rs2227255 | T | 1376 (68.9) | 600 (69.0) | 1005 (67.6) | 0.988 | 1.00 [0.84–1.19] | 0.412 | 1.06 [0.92–1.23] | 0.502 | 1.06 [0.89–1.28] |
| C | 620 (31.1) | 270 (31.0) | 481 (32.4) | |||||||
| T/T | 474 (47.5) | 205 (47.1) | 350 (47.1) | 0.946 | 0.309 | 0.329 | ||||
| T/C | 428 (42.9) | 190 (43.7) | 305 (41.0) | |||||||
| C/C | 96 (9.6) | 40 (9.2) | 88 (11.8) | |||||||
| rs2227258 | G | 1387 (69.5) | 604 (69.4) | 1002 (67.4) | 0.973 | 1.00 [0.84–1.19] | 0.195 | 1.10 [0.95–1.27] | 0.316 | 1.10 [0.92–1.31] |
| A | 609 (30.5) | 266 (30.6) | 484 (32.6) | |||||||
| G/G | 481 (48.2) | 207 (47.6) | 349 (47.0) | 0.911 | 0.147 | 0.183 | ||||
| G/A | 425 (42.6) | 190 (43.7) | 304 (40.9) | |||||||
| A/A | 92 (9.2) | 38 (8.7) | 90 (12.1) | |||||||