Table 4.
The inheritance model analysis of the ten SNPs in miRNA genes among CIN and Cervical cancer groups
| SNPs | Models | Genotypes | CC | CIN | OR (95 CI) | P value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
| rs1292037 | Codominant | T/T | 268 (36.1) | 138 (31.7) | 1.00 | 0.010 | 1548.3 | 1563.5 |
| T/C | 339 (45.6) | 237 (54.5) | 1.36 (1.04–1.77) | |||||
| C/C | 136 (18.3) | 60 (13.8) | 0.86 (0.59–1.24) | |||||
| Dominant | T/T | 268 (36.1) | 138 (31.7) | 1.00 | 0.130 | 1553.3 | 1563.4 | |
| T/C-C/C | 475 (63.9) | 297 (68.3) | 1.21 (0.94–1.56) | |||||
| Recessive | T/T-T/C | 607 (81.7) | 375 (86.2) | 1.00 | 0.042 | 1551.5 | 1561.6 | |
| C/C | 136 (18.3) | 60 (13.8) | 0.71 (0.51–0.99) | |||||
| Overdominant | T/T-C/C | 404 (54.4) | 198 (45.5) | 1.00 | 0.003 | 1547.0 | 1557.1 | |
| T/C | 339 (45.6) | 237 (54.5) | 1.43 (1.12–1.81) | |||||
| Log-additive | – | – | – | 1.00 (0.84–1.18) | 0.970 | 1555.6 | 1565.7 | |
| rs13137 | Codominant | A/A | 268 (36.1) | 138 (31.7) | 1.00 | 0.011 | 1548.5 | 1563.7 |
| A/T | 338 (45.5) | 236 (54.2) | 1.36 (1.04–1.77) | |||||
| T/T | 137 (18.4) | 61 (14) | 0.86 (0.60–1.25) | |||||
| Dominant | A/A | 268 (36.1) | 138 (31.7) | 1.00 | 0.130 | 1553.3 | 1563.4 | |
| A/T-T/T | 475 (63.9) | 297 (68.3) | 1.21 (0.94–1.56) | |||||
| Recessive | A/A-A/T | 606 (81.6) | 374 (86) | 1.00 | 0.048 | 1551.7 | 1561.8 | |
| T/T | 137 (18.4) | 61 (14) | 0.72 (0.52–1.00) | |||||
| Overdominant | A/A-T/T | 405 (54.5) | 199 (45.8) | 1.00 | 0.004 | 1547.1 | 1557.3 | |
| A/T | 338 (45.5) | 236 (54.2) | 1.42 (1.12–1.80) | |||||
| Log-additive | – | – | – | 1.00 (0.84–1.18) | 0.990 | 1555.6 | 1565.7 | |
| rs2745709 | Codominant | C/C | 260 (35) | 129 (29.7) | 1.00 | 0.010 | 1548.4 | 1563.6 |
| C/T | 358 (48.2) | 249 (57.2) | 1.40 (1.07–1.83) | |||||
| T/T | 125 (16.8) | 57 (13.1) | 0.92 (0.63–1.34) | |||||
| Dominant | C/C | 260 (35) | 129 (29.7) | 1.00 | 0.059 | 1552.0 | 1562.2 | |
| C/T-T/T | 483 (65) | 306 (70.3) | 1.28 (0.99–1.65) | |||||
| Recessive | C/C-C/T | 618 (83.2) | 378 (86.9) | 1.00 | 0.085 | 1552.6 | 1562.8 | |
| T/T | 125 (16.8) | 57 (13.1) | 0.75 (0.53–1.05) | |||||
| Overdominant | C/C-T/T | 385 (51.8) | 186 (42.8) | 1.00 | 0.003 | 1546.5 | 1556.7 | |
| C/T | 358 (48.2) | 249 (57.2) | 1.44 (1.13–1.83) | |||||
| Log-additive | – | – | – | 1.04 (0.87–1.24) | 0.690 | 1555.4 | 1565.6 | |
| rs2297537 | Codominant | C/C | 459 (61.8) | 302 (69.4) | 1.00 | 0.009 | 1548.1 | 1563.3 |
| C/G | 254 (34.2) | 125 (28.7) | 0.75 (0.58–0.97) | |||||
| G/G | 30 (4) | 8 (1.8) | 0.41 (0.18–0.90) | |||||
| Dominant | C/C | 459 (61.8) | 302 (69.4) | 1.00 | 0.008 | 1548.5 | 1558.6 | |
| C/G-G/G | 284 (38.2) | 133 (30.6) | 0.71 (0.55–0.92) | |||||
| Recessive | C/C-C/G | 713 (96) | 427 (98.2) | 1.00 | 0.032 | 1551.0 | 1561.1 | |
| G/G | 30 (4) | 8 (1.8) | 0.45 (0.20–0.98) | |||||
| Overdominant | C/C-G/G | 489 (65.8) | 310 (71.3) | 1.00 | 0.052 | 1551.8 | 1562.0 | |
| C/G | 254 (34.2) | 125 (28.7) | 0.78 (0.60–1.00) | |||||
| Log-additive | – | – | – | 0.71 (0.57–0.89) | 0.003 | 1546.6 | 1556.7 | |
| rs2297538 | Codominant | G/G | 535 (72) | 315 (72.4) | 1.00 | 0.002 | 1544.6 | 1559.9 |
| A/G | 191 (25.7) | 93 (21.4) | 0.83 (0.62–1.10) | |||||
| A/A | 17 (2.3) | 27 (6.2) | 2.70 (1.45–5.03) | |||||
| Dominant | G/G | 535 (72) | 315 (72.4) | 1.00 | 0.880 | 1555.6 | 1565.7 | |
| A/G-A/A | 208 (28) | 120 (27.6) | 0.98 (0.75–1.28) | |||||
| Recessive | G/G-A/G | 726 (97.7) | 408 (93.8) | 1.00 | 0.001 | 1544.4 | 1554.5 | |
| A/A | 17 (2.3) | 27 (6.2) | 2.83 (1.52–5.25) | |||||
| Overdominant | G/G-A/A | 552 (74.3) | 342 (78.6) | 1.00 | 0.092 | 1552.7 | 1562.9 | |
| A/G | 191 (25.7) | 93 (21.4) | 0.79 (0.59–1.04) | |||||
| Log-additive | – | – | – | 1.13 (0.91–1.40) | 0.280 | 1554.4 | 1564.6 |