Fig. 1.

Treatment with the Schistosoma japonicum small molecule peptide, SJMHE1, alleviated colon inflammation in mice with DDS-induced acute colitis. a Experimental scheme. C57BL/6 mice were provided with drinking water containing 2.5% DSS for 10 days. They were injected with SJMHE1 or PBS emulsified in IFA on days 0 and 7. The mice were killed on day 10. bDisease activity index (b) and rate of body weight change (c) in each group. d Macroscopic appearance of colon. e Colon length in each group. f Histological analysis of the colon from mice with H&E staining (magnification 20×). Images represent the results of three independent experiments (total n = 18 mice, 6 mice per group). g Histological scores were assessed from each mouse. Data are presented as mean ± standard error of the mean (SEM; n = 18) of three independent experiments. Asterisks indicate significant difference at: *P < 0.05, **P < 0.01, ***P < 0.001