Fig. 5.

SJMHE1 treatment protects against the induction of chronic colitis by DSS in mice. a Experimental scheme. C57BL/6 mice were provided with drinking water containing 2% DSS on days 0–5, 10–15, and 20–25. Mice were injected with SJMHE1 or PBS emulsified in IFA on days 0, 14 and 28. The mice were killed on day 30. b DAI (b) and rate of body weight change (c) in each group. d Macroscopic appearance of the colon. e Colon length in each group. f Histological analysis of the colon from mice by H&E staining (magnification 20×). Images represent three independent experiments (total n = 18 mice, 6 mice per group. g Histological scores were assessed from each mouse. Data are presented as the mean ± SEM (n = 18) from three independent experiments. Asterisks indicate significant difference at: *P < 0.05, **P < 0.01, ***P < 0.001