Figure 3: Changes in SSTR2 protein expression in vitro.
(A) The average basal expression level of SSTR2 in QGP-1 is higher than BON-1. The average basal SSTR2 expression in the pancreatic adenocarcinoma cell lines (MiaPaCa2 and PANC-1) is lower than both pancreatic neuroendocrine tumor cell lines (QGP-1 and BON-1). The non-cancerous cell line HEK293 was run as a positive control. (B) Expression of SSTR2 in QGP-1 (high basal SSTR2 expression) had a 1.7-fold maximum increase of SSTR2 expression with 1mM VPA, whereas (C) BON-1 (low basal SSTR2 expression) had 7.2-fold maximum increase in SSTR2 expression with 4mM VPA.