TABLE. Frequency of and risk for myocarditis among patients with and without COVID-19 and adjusted* myocarditis risk differences and risk ratios comparing patients with and without COVID-19 — Premier Healthcare Database Special COVID-19 Release, United States, March 2020–January 2021.
| Characteristic | No. of patients with COVID-19 | No. of patients without COVID-19 | No. of patients with myocarditis | Myocarditis among patients with COVID-19 |
Myocarditis among patients without COVID-19 |
Adjusted myocarditis risk difference (95% CI) | Adjusted myocarditis risk ratio (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| No. (% of patients with myocarditis) | Risk, % | No. (% of patients with myocarditis) | Risk, % | ||||||
|
Overall
|
1,452,773 |
34,552,521 |
5,069 |
2,116 (41.7) |
0.146 |
2,953 (58.3) |
0.009 |
0.126 (0.112–0.140) |
15.7 (14.1–17.2) |
|
Sex
| |||||||||
| Male |
680,722 |
14,339,356 |
3,008 |
1,274 (42.4) |
0.187 |
1,734 (57.6) |
0.012 |
0.165 (0.146–0.183) |
13.8 (12.3–15.3) |
| Female |
772,051 |
20,213,165 |
2,061 |
842 (40.9) |
0.109 |
1,219 (59.1) |
0.006 |
0.100 (0.087–0.113) |
17.8 (15.6–20.0) |
|
Age group, yrs
| |||||||||
| <16 |
64,898 |
3,670,762 |
218 |
86 (39.4) |
0.133 |
132 (60.6) |
0.004 |
0.122 (0.065–0.179) |
36.8 (25.0–48.6) |
| 16–24 |
123,865 |
3,067,575 |
511 |
121 (23.7) |
0.098 |
390 (76.3) |
0.013 |
0.088 (0.061–0.115) |
7.4 (5.5–9.2) |
| 25–39 |
268,549 |
6,246,568 |
862 |
208 (24.1) |
0.077 |
654 (75.9) |
0.010 |
0.067 (0.052–0.081) |
6.7 (5.5–8.0) |
| 40–49 |
198,561 |
4,147,909 |
620 |
213 (34.4) |
0.107 |
407 (65.6) |
0.010 |
0.093 (0.078–0.109) |
10.0 (8.1–11.9) |
| 50–64 |
356,697 |
7,965,264 |
1,226 |
553 (45.1) |
0.155 |
673 (54.9) |
0.008 |
0.137 (0.121–0.154) |
17.0 (14.7–19.3) |
| 65–74 |
214,331 |
5,318,474 |
801 |
398 (49.7) |
0.186 |
403 (50.3) |
0.008 |
0.160 (0.135–0.184) |
23.0 (19.4–26.7) |
| ≥75 | 225,872 | 4,135,969 | 831 | 537 (64.6) | 0.238 | 294 (35.4) | 0.007 | 0.208 (0.179–0.237) | 31.6 (25.9–37.2) |
Abbreviation: CI = confidence interval.
* Adjusted risk differences and risk ratios for myocarditis during or after COVID-19 (reference group: no COVID-19), obtained from a single logit model with the following covariates: a three-way interaction between presence of COVID-19, sex, and age group, including lower-order interactions and main effects; race/ethnicity; payer type; hospital U.S. Census region; and hospital urbanicity.