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. 2021 Aug 26;13(8):1030–1048. doi: 10.4252/wjsc.v13.i8.1030

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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An overview as to how mesenchymal stem cells promote neurogenesis and neurological recovery. Mesenchymal stem cells (MSCs) are isolated and identified from various tissue sources. These MSCs produce different angiogenic and neurotrophic factors by paracrine mechanisms in order to act on astrocytes, microglia, oligodendrocytes, and angiogenesis, promoting neurological recovery and neurogenesis. IGF-1: Insulin-like growth factor 1; BDNF: Brain-derived neurotrophic factors; VEGF: Vascular endothelial growth factors; HGF: Hepatocyte growth factor; NAP-2: Neutrophil activating protein 2; PDGF: Platelet-derived growth factor; Ang-1: Angiopoietin-1; MSC: Mesenchymal stem cell.