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. 2021 Sep 7;11(5):559–567. doi: 10.1557/s43579-021-00072-6

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© Helmholtz-Zentrum Hereon 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Physicochemical characterization of the cyclic olefin copolymer (COC)-based substrate. (I) Channel geometry: (a) µ-slide I Luer^0.4; (b) schematic image of the µ-slide I Luer^0.4 consisting of an upper cyclic olefin polymer (COP)-based part and a lower plasma-treated COC-based part functioning as a substrate for endothelial cells; (c) ESEM image of the cross section of the channel; (d) magnification of the left side of the channel showing the COP-based channel walls and the COC-based substrate used for cell adhesion. (II) Bulk characterization: (e) ¹³C NMR spectra of COC (top: inverse gated decoupling ¹³C with a d1 = 25 s, bottom: DEPT 135) and predicted chemical structure (f); (g) DSC curve and (h) WAXS curve of COC sample. III. Surface characterization: (i) ESEM image and (j) AFM height image of plasma-treated COC-based substrate surface; (k) ATR-FTIR spectrum of the plasma-treated (red) and non-treated (black) COC.