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. Author manuscript; available in PMC: 2021 Sep 7.
Published in final edited form as: Cell Rep. 2021 Aug 17;36(7):109549. doi: 10.1016/j.celrep.2021.109549

Figure 4. CD63 mediates the packaging of VEGF into sEVs.

Figure 4.

(A) Confocal images of cellular co-localization of VEGF and CD63. Scale bar, 20 μm.

(B) CoIP experiments of VEGF and CD63 proteins. Five micrograms of WCE from OVCAR5 and SKOV3 cells were used as input control. Arrowheads point to the location of VEGF isoforms.

(C) Upregulation of eVEGF levels in cells transduced with pCT-CD63-GFP virus particles. Arrowheads point to the location of VEGF isoforms.

(D) Downregulation of eVEGF levels after the knockdown of CD63 expression using shRNA. Arrowheads point to the location of VEGF isoforms.