TABLE 3.
Safety Outcomes of Sutured Artificial Iris and IOL Implantation Combined With Penetrating Keratoplasty
| ID | Length of Follow up (Mo) | CDVA (Snellen) Baseline–Final | Spherical Equivalent Refractive Error (D) | IOP (mm Hg) Baseline/Final | Postoperative Complications | Graft Rejection/Time From Surgery (Mo) | Secondary Graft Failure/Time From Surgery (Mo) | Secondary IOP Elevation (n Medications*)/Time From Surgery (Mo) | Secondary Surgical Interventions | Donor ECC (Cells/mm2) | Final ECC (Cells/mm2)† | Change in ECC (%) |
| 1 | 54.9 | CF–20/80 | 5.1 | 19/11 | Iritis (mild), self-cessation of topical corticosteroid | Yes/31.6 | Yes/35.3 | No | DSEK | 2950 | <500 | −83.1 |
| 2 | 44.6 | HM–20/80 | 1.1 | 20/16 | Iritis (mild) | No | No | Yes (5)/0.9 | Tube shunt implantation | 3106 | 1759 | −43.4 |
| 3 | 41.7 | 20/400–HM | 4.6 | 21/2 | CME, iritis (mild), band keratopathy, globe rupture with artificial iris and uveal tissue extrusion, graft dehiscence, RD, CD | No | Yes/37.7 | Yes (2)/0.9 | Tube shunt implantation, emergency globe closure, PPV with silicone oil injection plus PK | 3295 | <500 | −84.8 |
| 4 | 25.0 | HM–NLP | 1.3 | 9/2 | Iritis (mild), phthisis bulbi | Yes/11.5 | No | No | No | 2933 | 2020 | −31.1 |
| 5 | 33.9 | HM–20/30 | 0.3 | 13/8 | CME, iritis (moderate), RD | Yes/11.4 | Yes/19.4 | No | DSEK, PPV, scleral buckle | 3002 | <500 | −83.3 |
| 6 | 24.6 | LP–20/40 | 5.5 | 12/18 | Iritis (severe) | No | No | Yes (5)/0.9 | Tube shunt implantation, tube shunt revision ×2, strabismus repair, blepharoptosis repair, blepharoplasty | 2980 | 1832 | −38.5 |
| 7 | 13.0 | CF–20/63 | 0.0 | 11/29 | Iritis (mild) | Yes/11.6 | Yes/11.6 | Yes (2)/1.4 | DSEK | 3457 | <500 | −85.5 |
| 8 | 18.9 | HM–HM | 1.0 | 8/13 | Iritis (moderate) | Yes/0.5 | No | No | No | 3100 | 1300 | −58.1 |
| 9 | 19.2 | CF–20/25 | 0.0 | 23/5 | Iritis (moderate), RD | Yes/19.2 | Yes/19.2 | No | PK, tube shunt ligature, intravitreal corticosteroid injection, PPV, C3F8 gas injection | 2918 | 993 | −66.0 |
| 10 | 17.3 | 20/160–20/40 | 0.9 | 10/6 | Iritis (mild) | No | No | No | No | 3003 | 1549 | −48.4 |
| 11 | 19.1 | CF–20/125 | 1.5 | 12/6 | Iritis (mild), fungal keratitis, corneal perforation | Yes/3.3 | Yes/15.6 | No | Corneal patch graft, DSEK | 2959 | <500 | −83.1 |
| 12 | 13.2 | CF–20/125 | 1.3 | 21/9 | Iritis (mild), graft-host dehiscence (broken suture) | No | No | Yes (2)/0.5 | Wound revision | 2857 | 1767 | −38.2 |
| 13 | 8.0 | 20/200–20/25 | 2.0 | 15/16 | Iritis (severe), hyphema, vitreous hemorrhage | No | Yes/3.1 | No | AC washout, PK | 2865 | 2457 | −14.2 |
| 14 | 6.0 | CF–20/63 | 0.5 | 12/26 | CME, iritis (mild), exposed Gore-Tex suture | No | No | Yes (2)/1.3 | Scleral patch graft | 2865 | 1469 | −48.7 |
*
At the time of IOP elevation.
†
In case of repeat corneal transplantation, the last ECC available before repeat transplantation was used. When the ECC was <500 cells/mm2, 500 cells/mm2 was used to estimate the percentage change.
CD, choroidal detachment; CF, counting fingers; CME, cystoid macular edema; DSEK, Descemet-stripping endothelial keratoplasty; ECC, endothelial cell count; HM, hand motion; ID, patient identity; LP, light perception; NLP, no light perception; PK, penetrating keratoplasty; RD, retinal detachment.