TABLE 5.
Published Retrospective Studies of Sutured Custom Silicone Artificial Iris and IOL Implantation Combined With Penetrating Keratoplasty
| Journal, Year | First Author | N Eyes/N Combined With IOL and PK | Mean Follow Up (Mo) | Artificial Iris Trimming and Placement | Artificial Iris Fixation | IOL Fixation | Other Procedures | Safety Findings | Efficacy Findings |
| Graefes Arch exp ophthalmol, 2013 | Forlini | 4/2 | 6.0 (maximum) | Trimmed to 11 mm in combined cases, placed in the sulcus | Sutured to the sclera with 10-0 prolene, in patient 1 with 2 sutures and in patient 2 with 4 sutures | Sutured to the anterior face of the artificial iris in 1 patient and to the back face of the artificial iris in the other | Failed attempt to clip an iris claw IOL to both the posterior and the anterior faces of the artificial iris in 1 patient, mini-glaucoma tube shunt implantation in the other | Not mentioned | Artificial iris stable and centered in both eyes |
| Acta ophthalmol, 2016 | Spitzer | 34/5 | 24.0 | Not trimmed, placed in the sulcus | To the sclera with Z-sutures | IOL implantation performed in 13 eyes and PK in 5 eyes; of the 13 eyes receiving an IOL, it was sutured to the artificial iris in 7 eyes, sutured to the sclera in 3 eyes, placed in the ciliary sulcus in 2 eyes, and placed within the capsular bag in 1 eye | Peripheral iridectomy of the artificial iris in 31 eyes | CDVA worsening in 9 eyes, glaucoma and hypotony in 3 eyes each, persistent intraocular inflammation or CME in 7 eyes each, endothelial decompensation requiring additional corneal transplantation in 6 eyes, artificial iris repositioning in 4 eyes | Outcomes of the 5 PKs not mentioned specifically, improved CDVA in 25 eyes, improved glare sensitivity in 15 eyes |
| Eye, 2018 | Yoeruek | 5/5 | 24.6 | Horizontal CD minus 1 mm, placed in the sulcus | To the sclera with Z-sutures | Sutured to the back face of the artificial iris | Anterior vitrectomy in 2 eyes | Graft failure and uncontrolled IOP developed in 1 eye | Improved CDVA in 4 eyes, glare reduction in 2 eyes, artificial iris centered in all eyes |
CD, corneal diameter; CDVA, corrected distance visual acuity; CME, cystoid macular edema; IOL, intraocular lens; PK, penetrating keratoplasty.