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. 2021 Sep 7;16(9):e0256285. doi: 10.1371/journal.pone.0256285

Table 2. Details and allele frequencies of detected variants and mutations with a significant relation to low stress resilience.

No. Gene SNP number Nucleotide substitution Functional Consequence Number of persons with minor allele in group A Number of persons with minor allele in group B Number of persons with minor allele in group C Number of persons with minor allele in group D
1 DRD1 rs548677242 C/T Glu ⇒ Lys 57(15%) 76(60%) 32(13%) 45(39%)
2 DRD1 rs779186397 C/T Arg ⇒ Lys 34(9%) 76(60%) 38(16%) 76(66%)
3 DRD2 rs1076560 A/C Intron variant 23(6%) 68(55%) 43(18%) 58(49.5%)
4 DRD2 Novel mutation T/C Promoter 1(0.25%) 7(5.6%) 1(0.41%) 3(2.5%)
5 DRD3 rs6280 C/T Ser⇒ Gly 43(11%) 57(46%) 30 (12%) 22(19%)
6 DRD4 rs1800955 C/T Promoter 16(4%) 59(48%) 14(6%) 59(50%)
7 DRD5 rs2867383 A/G intron variant 19(5%) 80(65%) 17(7%) 33(28%)
8 DBH rs2283123 C/T intron variant 31(8%) 73(59%) 5(2%) 58(50%)
9 DBH rs1611115 C/T Upstream variant 70(18%) 86(69%) 48(20%) 71(61%)
10 COMT rs165599 A/G Intron variant 42(11%) 66(53%) 18(7%) 73(62%)
11 COMT rs4680 G/A Val⇒ Met 12(3%) 86(70%) 10(4%) 46(39%)
12 COMT Novel mutation G/A Promoter 1(0.25%) 6(4.8%) 1(0.41%) 4(3.4%)
13 COMT Novel mutation G/T Promoter 2(0.5%) 13(10%) 1(0.41%) 8(7%)
14 MAOA rs5906957 A/G Intron variant 47(12%) 57(45%) 30(12.5%) 34(29%)
15 BDNF rs6265 A/G Val⇒ Met 16(4%) 68(55%) 14(6%) 61(52%)
16 BDNF rs146354977 C/T Val⇒ Met 27(7%) 55(44%) 22(9%) 56(48%)
17 BDNF rs760902255 T/C Asn⇒ Asn 31(8%) 58(48%) 9(4%) 53(45%)
18 GDNF rs752541985 C/T Lys ⇒ Arg 16(4%) 88(71%) 17(7%) 82(70%)
19 GDNF Novel mutation A/T Lys ⇒Asn 1(0.25%) 11(6.4%) 1(0.41%) 3(2.5%)
20 5-HTT Novel mutation C/G Arg ⇒ Pro 2(0.5%) 14(10.8%) 1(0.41%) 8(7%)
21 5-HTT Novel mutation C/G Ala⇒ Pro 1(0.25%) 10(8%) 1(0.41%) 5(4.2%)
22 5-HTT rs25531 A/G Intron variant 32(8%) 59(48%) 16(7%) 72(62%)
23 DAT rs431905515 C/T Leu ⇒ Pro 16(4%) 98(79%) 19(8%) 83(71%)
24 DAT rs431905516 C/T Arg ⇒ Trp 17(4%) 89(72%) 26(11%) 80(69%)

mut: mutation, SNP: single nucleotide polymorphism, Chr: chromosome.