Table 2. Details and allele frequencies of detected variants and mutations with a significant relation to low stress resilience.
No. | Gene | SNP number | Nucleotide substitution | Functional Consequence | Number of persons with minor allele in group A | Number of persons with minor allele in group B | Number of persons with minor allele in group C | Number of persons with minor allele in group D |
---|---|---|---|---|---|---|---|---|
1 | DRD1 | rs548677242 | C/T | Glu ⇒ Lys | 57(15%) | 76(60%) | 32(13%) | 45(39%) |
2 | DRD1 | rs779186397 | C/T | Arg ⇒ Lys | 34(9%) | 76(60%) | 38(16%) | 76(66%) |
3 | DRD2 | rs1076560 | A/C | Intron variant | 23(6%) | 68(55%) | 43(18%) | 58(49.5%) |
4 | DRD2 | Novel mutation | T/C | Promoter | 1(0.25%) | 7(5.6%) | 1(0.41%) | 3(2.5%) |
5 | DRD3 | rs6280 | C/T | Ser⇒ Gly | 43(11%) | 57(46%) | 30 (12%) | 22(19%) |
6 | DRD4 | rs1800955 | C/T | Promoter | 16(4%) | 59(48%) | 14(6%) | 59(50%) |
7 | DRD5 | rs2867383 | A/G | intron variant | 19(5%) | 80(65%) | 17(7%) | 33(28%) |
8 | DBH | rs2283123 | C/T | intron variant | 31(8%) | 73(59%) | 5(2%) | 58(50%) |
9 | DBH | rs1611115 | C/T | Upstream variant | 70(18%) | 86(69%) | 48(20%) | 71(61%) |
10 | COMT | rs165599 | A/G | Intron variant | 42(11%) | 66(53%) | 18(7%) | 73(62%) |
11 | COMT | rs4680 | G/A | Val⇒ Met | 12(3%) | 86(70%) | 10(4%) | 46(39%) |
12 | COMT | Novel mutation | G/A | Promoter | 1(0.25%) | 6(4.8%) | 1(0.41%) | 4(3.4%) |
13 | COMT | Novel mutation | G/T | Promoter | 2(0.5%) | 13(10%) | 1(0.41%) | 8(7%) |
14 | MAOA | rs5906957 | A/G | Intron variant | 47(12%) | 57(45%) | 30(12.5%) | 34(29%) |
15 | BDNF | rs6265 | A/G | Val⇒ Met | 16(4%) | 68(55%) | 14(6%) | 61(52%) |
16 | BDNF | rs146354977 | C/T | Val⇒ Met | 27(7%) | 55(44%) | 22(9%) | 56(48%) |
17 | BDNF | rs760902255 | T/C | Asn⇒ Asn | 31(8%) | 58(48%) | 9(4%) | 53(45%) |
18 | GDNF | rs752541985 | C/T | Lys ⇒ Arg | 16(4%) | 88(71%) | 17(7%) | 82(70%) |
19 | GDNF | Novel mutation | A/T | Lys ⇒Asn | 1(0.25%) | 11(6.4%) | 1(0.41%) | 3(2.5%) |
20 | 5-HTT | Novel mutation | C/G | Arg ⇒ Pro | 2(0.5%) | 14(10.8%) | 1(0.41%) | 8(7%) |
21 | 5-HTT | Novel mutation | C/G | Ala⇒ Pro | 1(0.25%) | 10(8%) | 1(0.41%) | 5(4.2%) |
22 | 5-HTT | rs25531 | A/G | Intron variant | 32(8%) | 59(48%) | 16(7%) | 72(62%) |
23 | DAT | rs431905515 | C/T | Leu ⇒ Pro | 16(4%) | 98(79%) | 19(8%) | 83(71%) |
24 | DAT | rs431905516 | C/T | Arg ⇒ Trp | 17(4%) | 89(72%) | 26(11%) | 80(69%) |
mut: mutation, SNP: single nucleotide polymorphism, Chr: chromosome.