Table 1. Demographics and descriptive statistics for Norwegian Prescription Database groups used in time-dependent Cox regression analysis.
| Demographics 90DDD a Threshold: | NSAID(1) b | Sporadic(2) c | NSAID+ASA(3) d | ASA(4) e |
| Total Number: | 297.707 | 404.875 | 211.943 | 239.389 |
| Sex (Male %): | 37.4% | 46.8% | 46.0% | 55.7% |
| Follow-up time mean months (SD) | 78.4 (47.9) | 80.4 (43,9) | 86.9 (47.0) | 86.7 (43.2) |
| Total observation time (years) f | 2.683.756 | 2.713.360 | 1.980.983 | 1.730.596 |
| Total Immortal time(years) g | 738.825 | 446.623 | ||
| Mean age (SD) | 70.6 (9.2) | 68.7 (9.7) | 75.9 (9.5) | 76.0 (10.1) |
| Age 50–55 (%) | 2.867 (1%) | 13.578 (3%) | 319 (0.1%) | 1.119 (0.4%) |
| Age 55–60 (%) | 18.142 (6%) | 51.454 (13%) | 3299 (2%) | 7.498 (3%) |
| Age 60–65 (%) | 63.302 (21%) | 91.021 (22%) | 20.998 (10%) | 24.111 (10%) |
| Age 65–70 (%) | 72.863 (24%) | 85.557 (21%) | 36.891 (12%) | 36.909 (16%) |
| Age 70–75 (%) | 55.992 (19%) | 66.274 (16)% | 41.285 (17%) | 44.042 (18%) |
| Age 75–80 (%) | 32.923 (11%) | 37.162 (9%) | 33.911 (16%) | 36.268 (15%) |
| Age > 80 (%) | 51.618 (17%) | 59.829 (15%) | 75240 (36%) | 89.442 (37%) |
| Median cumulative NSAID DDD exposure h | 256 | 30 | 280 | 30 |
| Deaths (%) | 13.7% | 12.6% | 24.0% | 26.2% |
| Parkinson’s disease, Incidence number | 1.760 | 2.354 | 1.467 | 1.999 |
| Demographics 365DDD i Threshold | NSAID(1) a | NSAID+ASA(3) c | ||
| Total Number | 113.791 | 86.896 | ||
| Sex (Male %): | 32.6% | 41.2% | ||
| Follow-up time mean months (SD) | 76.1 (48.1) | 84.3 (47.2) | ||
| Total observation time (years) f | 1.127.242 | 875.701 | ||
| Total Immortal time(years) g | 405.196 | 265.054 | ||
| Mean age (SD) | 71.9 (9.1) | 76.3 (10.2) | ||
| Age 50–55 (%) e | 458 (0.4%) | 65 (0%) | ||
| Age 55–60 (%) | 3.973 (4%) | 811 (1%) | ||
| Age 60–65 (%) | 20.826 (18%) | 7.441 (9%) | ||
| Age 65–70 (%) | 28.184 (25%) | 15.036 (17%) | ||
| Age 70–75 (%) | 23.192 (20%) | 17.519 (20%) | ||
| Age 75–80 (%) | 14.156 (12%) | 14.624 (17%) | ||
| Age>80 (%) | 23.002 (20%) | 31.400 (36%) | ||
| Median cumulative NSAID DDD exposure d | 801 | 803 | ||
| Deaths (%) | 3.7% | 4.3% | ||
| PD Incidence number | 714 | 606 |
a) Minimum of 90 defined daily dose (DDD) exposure during follow up.
b) NSAID group(1).
c) Sporadic NSAID group(2).
d) NSAID+ASA group(3).
e) ASA group(4).
f) total time for all subjects from first NSAID prescription until endpoint in years.
g) total immortal time is the total time for all subjects until they reached the 90 or 365 cumulative DDD threshold.
h) median of cumulative defined daily dose NSAID exposure during follow up.
i) Minimum of 365 defined daily dose exposure during follow up.