TABLE 2.
Quinolone susceptibilities of 36 nalidixic acid-resistant Salmonella Typhimurium strains according to the presence of a mutation at Ser-83 (or possibly Asp-82)
| Quinolone | Mutation | No. of strains | MIC (μg/ml)
|
||
|---|---|---|---|---|---|
| Range | 50% | 90% | |||
| Nalidixic acid | At Ser-83 (or Asp-82) | 19 | 256–512 | 512 | 512 |
| No mutation at codon 82 or 83 | 17 | 16–256 | 16 | 256 | |
| Pefloxacin | At Ser-83 (or Asp-82) | 19 | 1–2 | 2 | 2 |
| No mutation at codon 82 or 83 | 17 | 0.112–1 | 0.5 | 1 | |
| Ciprofloxacin | At Ser-83 (or Asp-82) | 19 | 0.25–1 | 0.25 | 0.25 |
| No mutation at codon 82 or 83 | 17 | 0.03–0.25 | 0.06 | 0.12 | |