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CONSORT diagram of ctDNA sample collection and analysis. Baseline ctDNA was sequenced from 565 patients. All analyses focused on patients with evidence of tumor DNA in circulation with the presence of ≥ 1 genetic alteration. In all, 489 of 565 patients met all criteria and were subject to downstream analysis. ctDNA, circulating tumor DNA; ET, endocrine therapy; ITT, intention to treat.
