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. 2021 Sep 1;5:PO.20.00445. doi: 10.1200/PO.20.00445

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© 2021 by American Society of Clinical Oncology

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FIG 4. — Association of PFS with genes involved in cell cycle regulation: (A) PFS by CCND1 alteration status and (B) PFS by TP53 alteration status. Kaplan-Meier curves of PFS in patients who exhibited alterations in the indicated genes in circulating tumor DNA. PFS in patients in the ribociclib treatment arm is shown in red; in patients in the placebo treatment arm, it is shown in blue. The WT subgroup is indicated by a solid line, and the altered subgroup is indicated by a dashed line. HR (95% CI) estimates and median PFS (95% CI) values are shown in the corresponding tables. Alt, altered; HR, hazard ratio; NA, not achieved; PBO, placebo; PFS, progression-free survival; RIB, ribociclib; WT, wild-type.